Insilico Study of Type II Diabetes and Effective Drugs

Book Details:

• Publisher: LAP Lambert Academic Publishing

• Author: Satyavani Guttula

• Language: English

• Edition: 1st Edition

• ISBN: 9783848483204

• Pages: 128

• Cover: Paperback

• Dimensions: 8.7 x 5.9 x 0.3 inches

About the Book:

In Diabetes and Its Treatment: A Microarray Data Analysis Approach, Satyavani Guttula provides an insightful exploration of the growing global health issue of diabetes, with a particular focus on Type 2 diabetes. The book presents an analytical approach to understanding the disease through Microarray data, highlighting the importance of gene expression in diabetes research.

The author delves into the complexities of clustering genes that are most expressed in Type 2 diabetes, using phylogenetic analysis based on sequence similarity to examine expression rates. In addition, the book investigates the interaction between two key proteins—Beliverdine and Uroporphyrinogen—and eight widely used antidiabetic drugs, such as Acarbose, Gliquidone, Metformin, and others. These drugs serve as ligands, and the interactions with two receptors are studied through docking simulations to determine their effectiveness.

Ultimately, the book concludes that Acarbose is the most efficient drug, providing valuable insights for researchers, healthcare professionals, and those interested in the molecular and pharmacological aspects of diabetes treatment. This work is a valuable resource for anyone involved in diabetes research or the development of therapeutic strategies for managing the disease.