Drug Metabolism and Transport: Molecular Methods and Mechanisms (Methods in Pharmacology and Toxicology)

Author: Lash, Lawrence H.

Brand: Humana

Edition: 2005 ed.

Binding: hardcover

Format: Illustrated

Number Of Pages: 388

Release Date: 24-09-2004

Details: A compendium of proven experimental approaches and strategies for studying the bioactivation, detoxification, tissue distribution, and elimination of xenobiotics in the metabolism and/or transport of various chemicals. The authors address several of the major drug metabolizing systems, including the cytochrome P450 family, flavin-containing monooxygenases, glutathione, S-transferase, glucuronidation, N-acetylation, and sulfotransferases. Additional chapters present novel approaches to the study of: signaling pathways in the regulation of drug metabolism enzymes, how the modulation of thiols and other low molecular-weight cofactors can alter drug metabolism, and how modulation of drug metabolism pathways can influence antiviral therapy.

EAN: 9781588293244

Package Dimensions: 9.3 x 6.2 x 1.2 inches

Languages: English