SEQUENCE-SPECIFIC DNA BINDING AGENTS: Volume 6 (RSC Biomolecular Sciences)

Author: Waring, Michael J

Brand: Royal Society of Chemistry

Edition: Illustrated

Binding: hardcover

Format: Illustrated

Number Of Pages: 270

Release Date: 15-09-2006

Part Number: 9780854043705

Details: Product Description
The binding of antibiotics and drugs to DNA is a fast developing area of research with important applications in medicine, particularly the treatment of cancer. Sequence-specific DNA Binding Agents uniquely discusses key aspects of this topic, providing a novel perspective on the subject. Written by experts in the field, this book discusses diverse modes of binding of antibiotics and drugs to DNA, emphasising matters that are important or promising for cancer treatment. Chapters discuss established agents like actinomycin D but also look at novel drugs with strong potential in chemotherapy such as new topoisomerase inhibitors, telomerase inhibitors, peptide nucleic acids and triple helix-forming oligonucleotides. There are also sections discussing methodological advances including computational methods, slow kinetics, melting curve analysis and approaches to medicinal chemistry. Finally there is a section on RNA structure and its potential as a drug target. The book is ideal for researchers in industry and academia who require a comprehensive source of reference to this rapidly expanding subject.
Review
An excellent overview of the work being done in the exciting areas of discovering agents that exhibit selectivity and sequence specificity for DNA.Michael J Waring, who has been a pioneer in and made seminal contributions to this particular field.A comprehensive reference on this rapidly expanding field.....is a must read.....an excellent text book for a graduate course on this subject and a useful guide at the post-graduate level for biochemists as well as biophysicists. ―
ChemBioChem, 2007, 8, 459-460 (Fu-Mling Chen)
From the Back Cover
The binding of antibiotics and drugs to DNA is a fast developing area of research with important applications in medicine, particularly the treatment of cancer. Sequence-specific DNA Binding Agents uniquely discusses key aspects of this topic, providing a novel perspective on the subject.
Written by experts in the field, this book discusses diverse modes of binding of antibiotics and drugs to DNA, emphasising matters that are important or promising for cancer treatment. Chapters discuss established agents like actinomycin D but also look at novel drugs with strong potential in chemotherapy such as new topoisomerase inhibitors, telomerase inhibitors, peptide nucleic acids and triple helix-forming oligonucleotides. There are also sections discussing methodological advances including computational methods, slow kinetics, melting curve analysis and approaches to medicinal chemistry. Finally there is a section on RNA structure and its potential as a drug target.
The book is ideal for researchers in industry and academia who require a comprehensive source of reference to this rapidly expanding subject.
Excerpt. © Reprinted by permission. All rights reserved.
Sequence-Specific DNA Binding Agents

By Michael Waring
The Royal Society of Chemistry


Copyright © 2006 The Royal Society of Chemistry
All rights reserved.

ISBN: 978-0-85404-370-5


Contents

Chapter 1 DNA Recognition by Triple Helix Formation David A. Rusling, Tom Brown and Keith R. Fox, 1,
Chapter 2 Interfacial Inhibitors of Human Topoisomerase I Christophe Marchand and Yves Pommier, 29,
Chapter 3 Diversity of Topoisomerase I Inhibitors for Cancer Chemotherapy Nathalie Dias and Christian Bailly, 44,
Chapter 4 Slow DNA Binding L. Marcus Wilhelmsson, Per Lincoln and Bengt Nordén, 69,
Chapter 5 DNA Gene Targeting using Peptide Nucleic Acid (PNA) Peter E. Nielsen, 96,
Chapter 6 Actinomycin D: Sixty Years of Progress in Characterizing a Sequence-Selective DNA-Binding Agent David E. Graves, 109,
Chapter 7 Thermal Denaturation of Drug–DNA Complexes: Tools and Tricks Jonathan B. Chaires and Xiaochun Shi, 130,
Chapter 8 Computer Simulations of Drug–DNA interactions: A Personal Journey Federico Gago, 152,
Chapter 9 The Discovery of G-Quadruplex Telomere Targeting Drugs Stephen Neidle, 190

EAN: 9780854043705

Package Dimensions: 9.3 x 6.0 x 0.8 inches

Languages: English