Protein Crystallography: A Concise Guide

Book Details

• Author: Lattman, Eaton E.

• Brand: Johns Hopkins University Press

• Edition: 1

• Binding: Paperback

• Number of Pages: 152

• Release Date: 23-06-2008

• EAN: 9780801888083

• Package Dimensions: 8.8 x 5.9 x 0.5 inches

• Languages: English

About The Book:
The proteome remains one of the great mysteries of modern biology, with the structures of only a fraction of the proteins encoded by the human genome known. Protein crystallography, which uses X-ray diffraction to reveal the three-dimensional molecular structures of proteins, remains the primary method for determining these structures.

In this concise and accessible primer, Eaton E. Lattman and Patrick J. Loll provide a detailed introduction to the principles and methods of protein crystallography. The book offers clear explanations and abundant illustrations to help beginners understand the process of using diffraction techniques to solve protein structures. Topics include the behavior of two- and three-dimensional crystals, phase determination methods such as MIR and MAD phasing, molecular replacement, the Patterson function, and refinement.

The authors' crisp writing style and simplified illustrations provide an ideal guide for those new to protein crystallography, making complex concepts more accessible to students, researchers, and those entering the field.